Inhibition of Acetylcholinesterase Activity by Aromatic Chelating Agents
نویسندگان
چکیده
منابع مشابه
"in vitro inhibition of human erythrocyte acetylcholinesterase activity by zinc and mercury "
the effects of zinc and mercury on human erythrocyte acetylcholinestrase activity were studied. blood used in this study was obtained from 24 apparently healthy individuals and after hemolysation, was treted with 3 diferent concentrations of zinc and mercury. significant suppressions in acetylcholinestrase activity were recorded in treated samples by zinc and mercury. when compared to controls ...
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the effects of cadmium and lead on human erythrocyte acetylcholinesterase activity were studied. blood used in this study was obtained from 24 healthy individuals, then after hemolysation, treated with 3 various concentrations of cadmium and lead. a strong inhibition of acetylcholinesterase was noted in treated samples by cadmium and lead. the remaining activity in the case of lead, the remaini...
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Deferrioxamine B and rhodotorulic acid, iron-chelating agents of microbial origin, exerted a pronounced inhibitory effect on pathogenic Naegleria fowleri at microgram levels. This inhibition was diminished by adding iron to the chelators before incubation with Naegleria isolates. These and related microbial iron chelators occur naturally in the environment. This could be of considerable ecologi...
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The successful design of orally active non-toxic selective metal chelators is a much sought-after goal. In order to identify an ideal chelator for clinical use, a range of specifications must be considered, such as metal selectivity and affinity, kinetic stability of the complex, bioavailability and toxicity. In this overview the comparative properties of ligands capable of endowing complexes w...
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Itopride is a gastroprokinetic benzamide derivative. This agent inhibited both electric eel acetylcholinesterase (AChE) and horse serum butyrylcholinesterase (BuChE). The IC50 of itopride with AChE (2.04 +/- 0.27 microM) was, however, 100-fold less than that with BuChE, whereas in the case of neostigmine with AChE (11.3 +/- 3.4 nM), it was 10-fold less. The recovery of AChE activity inhibited b...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1973
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1973.tb02865.x